Women's Health Weekly
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Cancer Therapy
Tiron identified as bortezomib blocker
March 9th, 2006
Tiron was identified as a bortezomib blocker. According to recent research published in the Journal of Biological Chemistry, "The proteasome inhibitor bortezomib is emerging as a potent anti-cancer agent. Still, recent clinical trials have revealed a significant secondary toxicity of bortezomib. Consequently, there is much interest in dissecting the mechanism of action of this compound to rationally improve its therapeutic index." "The cytotoxic effect of bortezomib is frequently characterized by interfering with downstream events derived from the accumulation of proteasomal targets. Here we identify the first chemical agent able to act...
Source: Women's Health Weekly (2006-03-09)
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