Women's Health Weekly
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Apoptosis
Cathepsin B and its interacting proteins implicated in apoptosis of ovarian cancer cells
March 9th, 2006
Cathepsin B and its interacting proteins, bikunin and TSRC1, were implicated in the apoptosis of ovarian cancer cells. According to a study from the People's Republic of China, "Increasing evidence suggests that lysosomal cysteine proteases cathepsins contribute to the progression of cell apoptosis. Here we found that apoptosis of ovarian cancer cells OV-90 triggered by TNF was cathepsin B-depended." "Two cathepsin B binding proteins, bikunin and TSRC1, were identified by yeast two-hybrid method and the interactions were confirmed in vitro and in vivo. Overexpression of bikunin could suppress TNF-induced apoptosis of OV-90 cells, and TSRC1...
Source: Women's Health Weekly (2006-03-09)
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