Breast Cancer

Breast cancer risk higher in those with genetic variation in leptin and receptor

Published in Women's Health Weekly, March 16th, 2006

Individuals with either of two genetic variations that lead to high serum levels of the cytokine leptin and to overexpression of leptin in fatty tissue, are more at risk of developing breast cancer than others.

A study published February 19, 2006, in the open access journal BMC Cancer suggests that individuals with a specific genetic variation (polymorphism) in the gene LEP that encodes for leptin, or a polymorphism in the gene LEPR, encoding for its receptor, have an increased risk of breast cancer. This contradicts previous results that showed no link between the polymorphism in LEPR and the risk of breast cancer.

Both polymorphisms could be...

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Source: Women's Health Weekly (2006-03-16)

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