Women's Health Weekly
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Breast Cancer
EGFR overexpression and mutations are associated with breast cancer progression
March 16th, 2006
Amplifications of the epidermal growth factor receptor (EGFR) gene were associated with progression of phyllodes tumor of the breast. According to a study from Germany, "Phyllodes tumors of the breast are rare biphasic tumors with the potential for invasion and metastatic spread. An important role of the EGFR in phyllodes tumors has been proposed. However, detailed pathogenetic mechanisms remained unclear." "We investigated 58 phyllodes tumors of the breast (40 benign, 10 borderline and 8 malignant) by means of EGFR fluorescence in situ hybridization (FISH) and gene dosage PCR for a regulatory sequence within intron 1 of EGFR. Immunohistochemical...
Source: Women's Health Weekly (2006-03-16)
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