Women's Health Weekly
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Breast Cancer
Osteoclasts direct bystander killing of cancer cells in vitro
March 16th, 2006
According to recent research from the United States, osteoclasts direct bystander killing of cancer cells in vitro. "Cytosine deaminase (CD) catalyzes the deamination of 5-fluorocytosine (5FC) to produce the highly toxic chemotherapeutic agent 5-fluorouracil (5FU). A unique feature of the CD/5FC enzyme/prodrug system is its ability to kill adjacent cells via bystander killing," wrote M. Ramnaraine and colleagues, University of Minnesota. "Bystander killing of cancer cells can be mediated by non-cancerous accessory cells transduced with the CD gene; one type of non-cancerous accessory cell found in primary bone cancer and breast cancer metastases to...
Source: Women's Health Weekly (2006-03-16)
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