Cancer Gene Therapy
Anticancer gene vaccine inhibits human papillomavirus oncoprotein
Published in Women's Health Weekly, March 16th, 2006
"Adeno-associated virus (AAV) Rep 78 protein is known to inhibit the promoter site of several oncogenes and viral genes, including the human papillomavirus (HPV) type 16 E6 transforming genes."
"The biochemical studies of Rep 78 have been reported, but the effects of Rep 78 gene-mediated inhibition of HPV 16 E6 promoter activity on the various human cervical carcinoma cells have not been characterized," wrote W.S. Ahn and colleagues, Catholic University of Korea.
"pEGFP-N1 vector, cloned by AAV-mediated Rep 78, is...
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