Women's Health Weekly
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Cancer Gene Therapy
MT1-MMP down-regulation suppresses ovarian tumor cell invasion
March 16th, 2006
A study from the People's Republic of China has reported that the down-regulation of membrane-type 1 matrix metalloproteinase (MT1-MMP) expression suppresses tumor cell invasion in metastatic human SW626 ovarian cancer cells. "MT1-MMP/MMP-14 is a key enzyme involved in degradation of extracellular matrix (ECM) and various surface-associated proteins that control cell growth, differentiation and survival, plays crucial roles in molecular carcinogenesis, tumor cell growth, invasion, and angiogenesis." "We tested the inhibitory effect of antisense MT1-MMP on the ability of metastatic human ovarian carcinoma cell line SW626 in proliferation and...
Source: Women's Health Weekly (2006-03-16)
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