Women's Health Weekly
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Breast Cancer
Breast cancer linked to expression of autocrine motility factor
March 23rd, 2006
Breast cancer was linked to the expression of autocrine motility factor (AMF) and its receptor, AMFR. "AMF stimulates, via an autocrine route, the motility of cancer cells. The current study investigated the expression of AMF and its receptor, AMFR (gp78), in breast cancer and attempted to dissect a clinical link," scientists in the United Kingdom reported. "Breast tumor tissues (n=120) and non-neoplastic normal tissues (n=32) were studied. AMF and AMFR distribution in tissues were assessed using immunohistochemistry and their transcripts were analyzed using RT-PCR and quantitative PCR. Median follow-up of the cohort was 10 years. Normal mammary...
Source: Women's Health Weekly (2006-03-23)
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