Women's Health Weekly
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Breast Cancer
Breast cancer treated by possible antimetastatic formylated hexapeptide ligand
March 23rd, 2006
Formyl-Met-Asp-Gly-Cys-Glu-Leu peptide ligand demonstrated a potential use in antimetastatic treatment of breast cancer. "Loss of Wnt-5a protein expression is associated with shorter recurrence-free survival in breast carcinoma patients and increased motility in mammary cell lines. Based on sequence analysis of Wnt-5a, we identified 14 peptide fragments and investigated their ability to mimic the effects of Wnt-5a on mammary cell adhesion and migration," scientists in Sweden reported. "Two of these peptides significantly increased adhesion and impaired migration in the non-tumorigenic HB2 breast epithelial cell line and in the MDA-MB468 breast cancer...
Source: Women's Health Weekly (2006-03-23)
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