Women's Health Weekly
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Breast Cancer
Breast carcinoma cells receive support from vascular endothelial growth factor-D
March 23rd, 2006
Breast carcinoma cells receive support from vascular endothelial growth factor-D (VEGF-D). According to a study from the United States, "VEGF-D stimulates growth of vascular and lymphatic endothelial cells by signaling through the tyrosine kinase receptors KDR (VEGFR-2) and Flt-4 (VEGFR-3). In the present study, we examined the effects of VEGF-D on apoptosis in human MCF-7 and MDA-MB-231 breast carcinoma cells." "Because VEGF-D was not expressed constitutively in vitro, stable VEGF-D transfectants were produced. The VEGF-D-expressing MCF-7 and MDA-MB-231 lines displayed resistance to apoptosis induced by hypoxia, staurosporin and cycloheximide....
Source: Women's Health Weekly (2006-03-23)
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