Women's Health Weekly
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Breast Cancer
Hirsutenone inhibits COX-2 and MMP-9 upregulation in mammary epithelial cells
March 23rd, 2006
Research from South Korea has reported that hirsutenone inhibits phorbol ester-induced upregulation of cyclooxygenase-2 (COX-2) and matrix metalloproteinase-9 (MMP-9) in cultured human mammary epithelial cells. "Inappropriate upregulation of COX-2 and MMPs has been implicated in the pathogenesis of various types of cancer," wrote J.H. Kim and colleagues, Seoul National University. "In the present study, we investigated the effects of hirsutenone, a diarylheptanoid isolated from the medicinal plant Alnus hirsuta var. sibirica, on the expression of COX-2 and MMP-9 induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) in MCF10A...
Source: Women's Health Weekly (2006-03-23)
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