Women's Health Weekly
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Breast Cancer Vaccine
IL-12 and GM-CSF microsphere therapy eradicates tumors but does not provide long-term cure
March 23rd, 2006
Interleukin-12 plus GM-CSF microsphere therapy eradicates advanced spontaneous tumors in her-2/neu transgenic mice but fails to achieve long-term cure due to the inability to maintain effector T cell activity. According to recent research from the United States, "A single intratumoral injection of interleukin-12 and granulocyte-macrophage colony-stimulating factor-encapsulated microspheres induced the regression of advanced spontaneous mammary tumors, suppressed additional tumor development, and enhanced survival in her-2/neu transgenic mice. Post-therapy tumor eradication was dependent on both CD4+ and CD8+ T cells and correlated with the tumor...
Source: Women's Health Weekly (2006-03-23)
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