Women's Health Weekly
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Cancer Gene Therapy
RNA interference induces cell cycle arrest and apoptosis in breast carcinoma cells
March 23rd, 2006
According to recent research from the United States, RNA interference-mediated depletion phosphoinositide 3-kinase (pI3K) activates forkhead box class O transcription factors and induces cell cycle arrest and apoptosis in breast carcinoma cells. "Breast cancer is one of the most common malignancies affecting women in the Western world and one in seven women is predicted to develop invasive breast cancer in their lifetime. Breast cancer arises following the accumulation of a series of somatic changes often including deregulation of key signal transduction pathways," wrote S. Reaganshaw and colleagues, University of Wisconsin. They explained, "The pI3K...
Source: Women's Health Weekly (2006-03-23)
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