Women's Health Weekly
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Cancer Therapy
Researchers' findings advance cancer therapy research
March 23rd, 2006
Investigators in France, the United States and Italy have published new cancer therapy data. Study 1: Piperazinobenzopyranones and phenalkylaminobenzopyranones could be used to inhibit breast cancer resistance protein (ABCG2). "In continuing research that led us to identify chromanone derivatives (J Med Chem 2003, 46, 2125) as P-glycoprotein inhibitors, we obtained analogues able to modulate multidrug resistance (MDR) mediated by the breast cancer resistance protein (BCRP). The linkage of 5-hydroxybenzopyran-4-one to piperazines or phenalkylainines affords highly potent inhibitors of BCRP. By using sensitive (HCT116) and resistant colon cancer cells...
Source: Women's Health Weekly (2006-03-23)
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