Ovarian Cancer
Effective ovarian cancer treatment strategies target Raf-1 mRNA
Published in Women's Health Weekly, April 10th, 2006
"In this study, we characterize the uptake and specificity of a first-generation Raf-1 antisense oligonucleotide (ASO) (ISIS 5132) and compare it with a second-generation ASO (ISIS 13650) and an RNA interference approach," wrote P. Mullen and colleagues, University of Edinburgh.
They continued, "All three approaches resulted in inhibition of both Raf-1 expression and cellular growth. Specificity of the Raf-1 ASOs was confirmed by comparison with ASOs targeted against another Raf isoform (B-Raf) as well as mismatch sequences.
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