Ovarian Cancer
Mdr-1 polymorphism G2677T/A correlates with paclitaxel response in ovarian cancer
Published in Women's Health Weekly, April 10th, 2006
"P-glycoprotein, encoded by the mdr-1 gene, confers multidrug resistance to a variety of antineoplastic agents, e.g., paclitaxel. Recently, different polymorphisms in the mdr-1 gene have been identified and their consequences for the function of P-glycoprotein, as well as for the treatment response to P-glycoprotein substrates, are being clarified," scientists in Sweden reported.
"We analyzed the allelic frequencies at polymorphic sites G2677T/A and C3435T in ovarian cancer patients with good or poor response to treatment with...
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