Endometrial Cancer
Endometrial carcinoma chemoresistance involves placental leucine aminopeptidase
Published in Women's Health Weekly, April 10th, 2006
"In several recent studies, we have shown that P-LAP can be a poor prognostic factor and a factor of chemoresistance in endometrial carcinoma, especially in the advanced patients. In our study, we investigated whether P-LAP alters the expression of apoptosis regulatory proteins as a mechanism of drug resistance," wrote C. Kondo and colleagues, Nagoya University. "We transfected P-LAP cDNA into A-MEC cells (endometrial adenocarcinoma cell line), and A-MEC-LAP cells displayed a 1.8-fold, 2.0-fold and 1.7-fold increase in IC50 against...
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