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Polycystic Ovary Syndrome

Polycystic ovary syndrome may be associated with reduced leptin receptor levels

Published in Women's Health Weekly, April 17th, 2006

A recent study describes decreased soluble leptin receptor levels in women with polycystic ovary syndrome.

According to a report from Germany, "Polycystic ovary syndrome (PCOS) is associated with insulin resistance and a high incidence of obesity. Leptin, the product of the ob gene, is involved in the regulation of energy balance and obesity and circulates in both free and bound forms."

"The soluble leptin receptor (sOB-R) is the most important leptin-binding protein, thus influencing the biologically active free leptin level," explained S. Hahn and colleagues of the University of Duisburg-Essen. "We assessed the correlation of metabolic and...

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