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Atherosclerosis

Atherosclerosis risk may be reduced by weight loss-induced changes in cathepsin S level

Published in Women's Health Weekly, May 1st, 2006

Atherosclerosis risk may be reduced in obese women by weight loss-induced changes in cathepsin S level.

Investigators at the National Institute of Health and Medical Research in Paris wrote, "Human adipose tissue produces several adipokines, including the newly identified protein cathepsin S (CTSS), a cysteine protease involved in the pathogenesis of atherosclerosis. Obesity is characterized by high levels of CTSS in the circulation and in sc white adipose tissue (scWAT). We investigated the effect of surgery-induced weight loss on circulating CTSS and its protein expression in scWAT."

S. Taleb and colleagues explained, "Fifty morbidly obese women...

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