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Breast Cancer Vaccine

HER2/neu peptide induces epitope spreading in early stage breast cancer

Published in Women's Health Weekly, May 22nd, 2006

Vaccination with a HER2/neu peptide induces intra- and inter-antigenic epitope spreading in patients with early stage breast cancer.

According to recent research from the United States, "We are conducting clinical vaccine trials with the HER2/neu peptide, E75, in patients with breast cancer. The purpose of this study was to demonstrate clonal expansion of E75-specific CD8+ T cells and to identify intra- and inter-antigenic epitope spreading. Pre-and post-vaccination peripheral blood leukocyte samples (24 node-positive [NP] and 20 node-negative [NN]) from 44 vaccinated patients were analyzed."

"HLA-A2:Ig dimer molecules were loaded with the HER2...

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