Tubulolobular Cancer
Tubulolobular carcinoma of the breast may not be a variant of lobular carcinoma
Published in Women's Health Weekly, June 12th, 2006
According to recent research from Japan, "TLC of the breast is a rare subtype of breast carcinoma categorized by Fisher et al. (Hum Pathol 8:679-683, 1977) as a tubular variant of lobular carcinoma. E-cadherin is a transmembrane glycoprotein, and complete loss of E-cadherin expression has been observed in invasive lobular carcinoma."
"Ductal carcinoma retains at least some expression of E-cadherin. Moreover, the adhesive function of E-cadherin is dependent on the integrity of the catenin components, which link E-cadherin to the actin...
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