Published in Women's Health Weekly, July 6th, 2006
"We have previously shown that sensory nerve peptides contribute to the pathogenesis of HSRs to paclitaxel in rats. Moreover, pemirolast, an antiallergic agent, reverses the HSRs to paclitaxel, although the mechanism is considered to result from the blockade of paclitaxel-induced release of sensory peptides, rather than the inhibition of histamine release," researchers in Japan reported.
"In the present study, we investigated the preventive effect of pemirolast against acute HSRs in a...
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