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Cervical Cancer

Low podoplanin expression predicts poor prognosis in advanced-stage squamous cell carcinoma

Published in Women's Health Weekly, July 6th, 2006

Low podoplanin expression predicts poor prognosis in advanced-stage squamous cell carcinoma.

"Lymphatic invasion and nodal metastasis are predictors of poor outcome in cervix carcinoma. We have recently found that low podoplanin immunoreactivity in cervix carcinoma correlated with the presence of lymphatic invasion and nodal metastasis.

"In the current study, we examined whether podoplanin expression in pretreatment cervical biopsies can predict the presence lymphatic invasion, nodal metastasis, and outcome in advanced-stage tumors treated by nonsurgical means," researchers in the United States report.

"Podoplanin expression was...

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