Breast Cancer
Breast cancer cell survival requires acetyl-CoA carboxylase alpha
Published in Women's Health Weekly, July 13th, 2006
"Activation of de novo fatty acid synthesis is a characteristic feature of cancer cells. We have recently described an interaction between ACC alpha, a key enzyme in fatty acid synthesis, and BRCA1, which indicates a possible connection between lipid synthesis and genetic factors involved in susceptibility to breast and ovarian cancers," wrote V. Chajes and colleagues, Institut Gustave Roussy.
"For this reason, we explored the role of ACC alpha in breast cancer cell survival using an RNA interference (RNAi) approach. We show that...
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