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Endocrinology

Estrogen and weight loss decrease iso-induced Fos immunoreactivity and AT1 receptor activity

Published in Women's Health Weekly, July 20th, 2006

Estrogen and weight loss decrease isoproterenol-induced Fos immunoreactivity and angiotensin type 1 mRNA in the subfornical organ of female rats.

According to recent research from the United States, "Studies from our laboratory and others show that estrogen reduces angiotensin II (Ang II)-induced water intake by ovariectomized rats. Elimination of endogenous estrogen by ovariectomy causes weight gain that can be reversed or prevented by estrogen replacement. Changes in body weight modify cardiovascular responses to Ang II but whether such changes have similar effects on central and behavioral responses to Ang II is unknown."

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