Breast Cancer
Breast cancer progression influenced by integrin alpha-2 and beta-3 gene polymorphisms
Published in Women's Health Weekly, August 3rd, 2006
According to a study from Austria, "Integrins are cell surface receptors, which mediate cell-to-cell and cell-to-extracellular matrix adhesion. Some of them, e.g. alpha(V)beta(3), alpha(IIb)beta(3) and alpha(II)beta(1), have been suggested as key players for cancer development and tumor metastasis."
"Two polymorphisms in the gene for the alpha(II) component, ITGA2 807C >T and 1648G >A, have been associated with the cell-surface density of integrin alpha(II)beta(1). The 176T >C polymorphism in the ITGB3 gene, encoding the beta(3)...
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