Breast Cancer
Breast cancer tumorigenesis linked to loss of RAB25 expression
Published in Women's Health Weekly, August 3rd, 2006
"A novel breast cancer cell line (RAO-3) was established by transduction of the Q61L mutant RAS into human mammary epithelial cells that were immortalized with catalytic subunit of telomerase (hTERT). The cells displayed anchorage-independent growth and proliferation, and formed human mammary spindle cell carcinoma when injected into nude mice. Chromosome locus 1q22-23 was partially duplicated and inverted on one of the 3 chromosomes present in the cell line," scientists writing in the International Journal of Cancer explained.
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