Ovarian Cancer
Ovarian cancer epithelial to mesenchymal transition requires endothelin-1
Published in Women's Health Weekly, August 10th, 2006
"In a range of human cancers, tumorigenesis is promoted by activation of the endothelin A receptor (ETAR)/ET-1 axis. ET-1 and ETAR are overexpressed in primary and metastatic ovarian carcinomas, and high levels of ET-1 are detectable in patient ascites, suggesting that ET-1 may promote tumor dissemination," scientists in Italy report.
"Moreover, in these tumors, engagement of ETA receptor by ET-1 triggers tumor growth, survival, angiogenesis, and invasiveness. Thus, ET-1 enhances the secretion of matrix metalloproteinases, disrupts intercellular communications, and...
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