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Gene Research

Gene recombination can be temporally controlled in astrocytes

Published in Women's Health Weekly, August 24th, 2006

According to recent research from Germany, gene recombination is temporally controlled in astrocytes by transgenic expression of the tamoxifen-inducible DNA recombinase variant CreERT2.

"Inducible gene modification using the Cre/loxP system provides a valuable tool for the analysis of gene function in the active animal. GFAP-Cre transgenic mice have been developed to achieve gene recombination in astrocytes, the most abundant cells of the central nervous system, with pivotal roles during brain function and pathology," wrote P.G. Hirrlinger and colleagues, Max-Planck Institute for Experimental Medicine.

They explained, "Unfortunately, these mice...

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