Sexual & Reproductive Health
Altered neuropeptide secretion may underlie female reproductive ageing
Published in Women's Health Weekly, September 7th, 2006
"A large body of evidence suggests that a defect in the hypothalamic function may be the primary cause of reproductive ageing in female rats. We have previously shown that luteinising hormone (LH)-surge associated changes in hypothalamic NPY gene expression and median eminence (ME) NPY levels seen in young rats do not occur in middle-aged (MA) rats," wrote A. Sahu and colleagues, University of Pittsburgh.
"The present study examined whether hypothalamic NPY release is altered during the steroid-induced LH...
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