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Breast Cancer

Signal transducers and activators of transcription-3 decrease breast cancer invasiveness

Published in Women's Health Weekly, October 5th, 2006

Signal transducers and activators of transcription-3 up-regulate tissue inhibitor of metalloproteinase-1 expression and decrease invasiveness of breast cancer.

According to investigators in Canada, "Signal transducers and activators of transcription (STAT)-3 is an oncogenic protein that is constitutively activated in many human cancers, including 30 to 60% of primary breast cancer. The biological significance of STAT3 activation in breast cancer is not fully understood. We have previously shown that STAT3 up-regulates tissue inhibitors of metalloproteinase (TEMP)-1, a cytokine known to block metalloproteinases and decrease invasiveness in certain cancer cell...

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