Breast Cancer
New breast cancer tumor suppressor gene identified
Published in Women's Health Weekly, October 12th, 2006
According to a study from the United States, "Prostaglandin E-2 plays a growth-stimulatory role in breast cancer, and the rate-limiting enzyme in its synthesis, cyclooxygenase-2, is often overexpressed in these cancers. Little is known about the role of the key prostaglandin catabolic enzyme 15-PGDH in breast cancer pathogenesis."
"Using a pharmacologically based screen for epigenetically silenced genes, we found low levels of 15-PGDH in MDA-MB-231 cells [estrogen receptor (ER) negative] but high levels in MCF-7 cells (ER positive) and observed its...
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