Breast Cancer Vaccine
Targeting tumor-associated macrophages is new strategy against breast cancer
Published in Women's Health Weekly, October 12th, 2006
"Tumor-associated macrophages (TAMs) are associated with tumor progression and metastasis. We demonstrate for the first time that legumain, a member of the asparaginyl endopeptidase family functioning as a stress protein, overexpressed by TAMs, provides an ideal target molecule," researchers in the United States report.
"In fact, a legumain-based DNA vaccine served as a tool to prove this point, as it induced a robust CD8+ T cell response against TAMs, which dramatically reduced their density in tumor tissues and resulted in a marked decrease in pro-angiogenic factors...
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