Breast Cancer
Breast cancer patient responsiveness to chemotherapy might be predicted by GRP78
Published in Women's Health Weekly, October 19th, 2006
According to recent research from the United States, "The discovery of predictive factors for chemoresistance is critical for improving adjuvant therapy for cancer patients. The GRP78, widely used as an indicator of the unfolded protein response (UPR), is induced in the tumor microenvironment."
"In vitro studies suggest that GRP78 confers chemoresistance to topoisomerase inhibitors, such as Adriamycin (doxorubicin)," explained E. Lee and colleagues, University of California. "Here, we report on a...
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