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Breast Cancer

Breast cancer stage and prognosis correlated with telomere content

Published in Women's Health Weekly, November 2nd, 2006

Investigators found that breast cancer stage and prognosis correlated with telomere content (TC).

Researchers in the United States conducted a study "to evaluate the hypothesis that DNA TC in breast tumor tissue correlates with TNM staging and prognosis."

"Slot blot assay was used to quantitate TC in 70 disease-free normal tissues from multiple organ sites, and 2 independent sets of breast tumors containing a total of 140 samples," explained C.A. Fordyce and colleagues, University of New Mexico. "Non-parametric Rank-Sums tests, logistic regression and Cox proportional hazards models were used to evaluate the relationships between TC and tumor size,...

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