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Cancer Gene Therapy

Ovarian cancer gene transfer treatment evaluated in a xenograft model

Published in Women's Health Weekly, November 9th, 2006

Recent research from France has chronicled the in vivo expression and antitumor activity of p53 gene transfer with naked plasmid DNA in an ovarian cancer xenograft model in nude mice.

"Abnormalities in the p53 and p16 tumor suppressor genes are one of the most common occurrences associated with human neoplasia. Consequently, restoration of wild-type p53 or p16 functions is seen as a particularly promising approach for cancer gene therapy. In vitro and in vivo data have demonstrated that virus-mediated p53 gene transfer can induce active cell death and ovarian tumor regression," wrote P. Collinet and colleagues, University of Lille.

They continued...

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