Research findings, "Gene amplification, mutation, and protein expression of EGFR and mutations of ERBB2 in serousovariancarcinoma," are discussed in a new report. "EGFR and erbB-2 are targets for specific cancertherapy. The purpose of this study was to examine the frequency and clinicopathological correlations of gene amplification, protein expression, and mutations of EGFR and ERBB2 in serous carcinoma, the most common and aggressive type of ovarian cancer," investigators in Helsinki, Finland report.
"Tissue microarray constructed of 398 carcinomas was examined by chromogenic in situ hybridization (CISH) and by immunohistochemistry. Cases with amplification of EGFR...
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