Breast Cancer
Scientists at University of Manchester, Department of Medical Oncology detail research in breast cancer
Published in Women's Health Weekly, December 7th, 2006
Scientists discuss in "Pure oestrogen antagonists for the treatment of advanced breast cancer" new findings in breast cancer. According to a study from Manchester, the United Kingdom, "For more than 30 years, tamoxifen has been the drug of choice in treating patients with oestrogen receptor (ER)-positive breast tumours. However, research has endeavoured to develop agents that match and improve the clinical efficacy of tamoxifen, but lack its partial agonist effects."
"The first 'pure' oestrogen antagonist was developed in 1987; from this, an even more potent derivative was developed for clinical use, known as fulvestrant (ICI 182,780, 'Faslodex'). Mechanistic studies...
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