Angiogenesis
New angiogenesis findings from Karolinska Institut published
Published in Women's Health Weekly, December 28th, 2006
Investigators publish new data in the report "Estrogen receptor beta inhibits angiogenesis and growth of T47D breast cancer xenografts. Estrogens, which are stimulators of growth of both the normal breast and malignant breast, mediate their effects through two estrogen receptors (ER), namely ERalpha and ERbeta. ERalpha mediates the proliferative effect of estrogen in breast cancer cells, whereas ERbeta seems to be antiproliferative," investigators in Huddinge, Sweden report.
"We engineered ERalpha-positive T47D breast cancer cells to express ERbeta in a Tet-Off-regulated manner. These cells were then injected orthotopically into severe combined immunodeficient mice, and...
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