Breast Cancer Therapy
New findings from University of California in the area of breast cancer therapy described
Published in Women's Health Weekly, January 4th, 2007
A report, "Indole-3-carbinol selectively uncouples expression and activity of estrogen receptor subtypes in human breast cancer cells," is newly published data in Molecular Endocrinology. "Estrogen-responsive breast cancer cells, such as MCF7 and T47D cells, express both estrogen receptor (ER)-alpha (ERalpha) and ERbeta. Indole-3-carbinol (I3C) strongly down-regulated ERalpha protein and transcript levels, without altering the level of ERbeta protein, in both cell lines," scientists in the United States report.
"In cells transfected with the ERalpha promoter linked to a luciferase gene reporter, I3C ablated ERalpha promoter activity. Propyl pyrazole triol (PPT) is a...
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