Breast Cancer
New breast cancer findings from University of Massachusetts, Department of Cancer Biology published
Published in Women's Health Weekly, January 4th, 2007
Investigators publish new data in the report "Suppression of insulin receptor substrate 1 (IRS-1) promotes mammary tumor metastasis. The insulin receptor substrate (IRS) proteins are cytoplasmic adaptors that organize signaling complexes downstream of activated cell surface receptors. Here, we show that IRS-1 and IRS-2, despite significant homology, play critical yet distinct functions in breast cancer, and we identify specific signaling pathways that are influenced by IRS-1 using the polyoma virus middle-T (PyV-MT) transgenic mouse model of mammary carcinoma and Irs-1 null (Irs1(-/-)) mice," investigators in the United States report.
"The absence of Irs-1 expression...
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