Breast Cancer

Investigators at Northwestern University, Department of Pathology target breast cancer

Published in Women's Health Weekly, January 18th, 2007

New research, "Ligand-independent dimerization of the human prolactin receptor isoforms: functional implications," is the subject of a report. "Prolactin (PRL) contributes to the growth of normal and malignant breast tissues. PRL initiates signaling by engaging the PRL receptor (PRLr), a transmembrane (TM) receptor belonging to the cytokine receptor family," scientists in the United States report.

"The accepted view has been that PRL activates the PRLr by inducing dimerization of the receptor, but recent reports show ligand-independent dimerization of other cytokine receptors. Using coimmunoprecipitation assays, we have confirmed ligand-independent dimerization of the...

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Source: Women's Health Weekly (2007-01-18)

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