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Women's Health Weekly

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Breast Cancer Genetics



Research results from University of Cambridge, Department of Oncology update knowledge of breast cancer genetics



February 1st, 2007

A report, "HapMap-based study of the 17q21 ERBB2 amplicon in susceptibility to breast cancer," is newly published data in British Journal of Cancer. According to recent research from Switzerland, "ERBB2 is frequently amplified in breast tumours as part of a wide region of amplification on chromosome 17q21. This amplicon contains many candidate genes for breast cancer susceptibility."

"We used a genetic association study design to determine if common genetic variation (frequency >or=5%) in a 400-kb region surrounding ERBB2 and containing the PPARBP, CRK7, NEUROD2, PPP1R1B, STARD3, TCAP, PNMT, CAB2, ERBB2, C17ORF37, GRB7 and ZNFN1A3 genes, was associated with breast...


Source: Women's Health Weekly (2007-02-01)

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