Angiogenesis
Research from Duke University, Department of Medicine in angiogenesis provides new insights
Published in Women's Health Weekly, February 22nd, 2007
A new study, "The type III TGF-beta receptor suppresses breast cancer progression," is now available. According to recent research from the United States, "The TGF-beta signaling pathway has a complex role in regulating mammary carcinogenesis. Here we demonstrate that the type III TGF-beta receptor (TbetaRIII, or betaglycan), a ubiquitously expressed TGF-beta coreceptor, regulated breast cancer progression and metastasis."
"Most human breast cancers lost TbetaRIII expression, with loss of heterozygosity of the TGFBR3 gene locus correlating with decreased TbetaRIII expression. TbetaRIII expression decreased during breast cancer progression, and low TbetaRIII levels...
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