Ovarian Cancer Genetics
New research on ovarian cancer genetics from Northwestern University summarized
Published in Women's Health Weekly, March 22nd, 2007
New research, "Microenvironmental regulation of membrane type 1 matrix metalloproteinase activity in ovarian carcinoma cells via collagen-induced EGR1 expression," is the subject of a report. According to a study from the United States, "Late stage ovarian cancer is characterized by disseminated intraperitoneal metastasis as secondary lesions anchor in the type I and III collagen-rich submesothelial matrix. Ovarian carcinoma cells preferentially adhere to interstitial collagen, and collagen-induced integrin clustering up-regulates the expression of the transmembrane collagenase membrane type 1 matrix metalloproteinase (MT1-MMP)."
"Collagenolytic activity is important in...
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