Breast Cancer Genetics
New breast cancer genetics study findings have been reported by researchers at University of Verona
Published in Women's Health Weekly, June 21st, 2007
New investigation results, "Amino-bisphosphonates decrease hTERT gene expression in breast cancer in vitro," are detailed in a study published in Aging. "Human telomerase reverse transcriptase (hTERT) is the catalytic subunit of telomerase. hTERT expression and telomerase activity are elevated in most human tumors. Bisphosphonates play an important role in the management of tumors with the secondary involvement of bone," scientists in Verona, Italy report.
"We investigated the effect on hTERT gene expression of clodronate, alendronate, and pamidronate (from 10(-6) M to 10(-5) M) on MCF-7 and T47D human breast cancer cells, using real time RTPCR. At 10(-5) M,...
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