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Breast Cancer

Fluorescence diffuse optical tomography provides high contrast, 3-D look at breast cancer

Published in Women's Health Weekly, June 28th, 2007

Researchers at the University of Pennsylvania have created the first three-dimensional optical images of human breast cancer in patients based on tissue fluorescence.

Fluorescence diffuse optical tomography, or FDOT, relies on the presence of fluorophore molecules in tissue that re-radiate fluorescent light after illumination by excitation light of a different color. The reconstructed images demonstrated significant tumor contrast compared to typical endogenous optical contrast in breast. Tumor-to-normal tissue contrast based on FDOT with the fluorophore Indocyanine Green, or ICG, was two-to-four-fold higher than contrast based on endogenous contrasts such as hemoglobin...

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