Breast Cancer
Chiba University, Department of Thoracic Surgery reports research in breast cancer
Published in Women's Health Weekly, August 2nd, 2007
New research, "Methylation and gene silencing of the Ras-related GTPase gene in lung and breast cancers," is the subject of a report. "RRAD, a small Ras-related GTPase, is highly expressed in human skeletal muscle, lung, and heart. Although loss of expression of RRAD in breast cancer cells has been reported and it may act as an oncogene, the mechanism of silencing is unknown," scientists writing in the journal Annals of Surgical Oncology report.
"We examined (1) mRNA expression of RRAD in lung and breast cancer cell lines using RT-PCR and (2) methylation status of lung and breast cancers. Loss of RRAD expression was found in 14 of 20 (70%) NSCLC cell lines, 11 of...
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