Cancer Gene Therapy
Data on cancer gene therapy published by J.A. Vendrell and colleagues
Published in Women's Health Weekly, August 9th, 2007
Investigators publish new data in the report "A20/TNFAIP3, a new estrogen-regulated gene that confers tamoxifen resistance in breast cancer cells." According to recent research from Montpellier, France, "The zinc-finger protein A20/TNFAIP3, an inhibitor of nuclear factor-kappaB (NF-kappaB) activation, has been shown to protect MCF-7 breast carcinoma cells from TNF-alpha-induced apoptosis. As estrogen receptor (ER) status is an important parameter in the development and progression of breast cancer, we analysed the effect of 17beta-estradiol (E2) treatment on the expression of A20."
"We found that A20 is a new E2-regulated gene, whose expression correlates with ER...
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