Leukemia Epidemiology
Researchers from New York Medical College describe findings in leukemia epidemiology
Published in Women's Health Weekly, October 25th, 2007
A report, 'Incidence and clinical implications of GATA1 mutations in newborns with Down syndrome,' is newly published data in Blood. According to recent research from the United States, "'Somatic mutations in the GATA1 gene are present in almost all cases of Down syndrome (DS)-associated acute megakaryoblastic leukemia (AMKL) and transient leukemia (TL). An in utero origin of the GATA1 mutation suggests it is an early leukemogenic event."
"To determine the detectable incidence and clinical relevance of GATA1 mutations in DS newborns, we screened Guthrie cards from 590 DS infants for mutations in the GATA1 gene. Twenty-two (3.8%) of 585 evaluable infants harbored...
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